Increased Sulfatation of Orbital Glycosaminoglycans in Graves’ Ophthalmopathy1

Orbital endoscopic decompression in Graves Ophthalmopathy Summary

Increased response to oxidative stress challenge in Graves’ ophthalmopathy orbital fibroblasts

PURPOSE To investigate whether orbital fibroblasts from patients with Graves' ophthalmopathy (GO) are more responsive to oxidative stress. METHODS Lipid peroxidation, oxidative DNA damage, reactive oxygen species (ROS) contents and activities of antioxidant enzymes were measured in cultured orbital fibroblasts from GO patients and age-matched normal controls in response to 200 μM hydrogen per...

Graves' exophthalmos: Volumetric assessment of orbital expansion.

INTRODUCTION Graves' ophthalmopathy is characterized by an increase in the volume of orbital soft tissue contents and an associated increase in intraorbital pressure. Surgical expansion of bony orbital volume is therefore an effective method of treating moderate to severe exophthalmos. Numerous correlations between specific decompression procedures and reduction of proptosis have been made. The...

Idiopathic orbital inflammation and Graves ophthalmopathy.

Idiopathic orbital inflammation (IOI) is a poorly understood disease entity in which an orbital inflammatory process is found with, by definition, no identifiable local or systemic cause. Graves ophthalmopathy (GO) is often mentioned as a disease to exclude in the diagnosis of IOI. In the Orbital Clinic of the University Medical Center Utrecht, we have encountered 4 patients in whom diagnoses o...

Endoscopic orbital decompression for Graves' ophthalmopathy.

Graves' disease may occasionally result in significant proptosis that is either cosmetically unacceptable or causes visual loss. This has traditionally been managed surgically by external decompression of the orbital bony skeleton. Trans-nasal endoscopic orbital decompression is emerging as a new minimally-invasive technique, that avoids the need for cutaneous or gingival incisions. Decompressi...